Parkinson disease is a degenerative disease of the nervous system without a long-term treatment. Since a person’s risk for developing Parkinson disease can be inherited, significant insight to develop new treatments can be gained from understanding the biology of these genetic risks. Our understanding of the disease mechanism is currently impeded by the lack of human neurons that can be grown in the laboratory with an authentic genetic background. With recent technological advances, scientists can now change patient’s skin cells into a type of cell (an induced pluripotent stem cell or iPS cell) that can be directed to grow in the laboratory to become any cell type of the body, including neurons. With this bold technology, induced pluripotent stem cells from patients with a genetic form of Parkinson disease can provide an opportunity to investigate the mechanisms of neurodegeneration in different types of neurons.
Our Consortium of 6 research teams are generating and characterizing neurons grown from Parkinson disease patient-specific neurons to generate a basis for future research and potential drug discovery systems that can be tailored towards an individual’s genetic risk factors.
Coriell Cell Repositories
Consortium Contact Information
The coordinating principal investigator of the Consortium is Professor Ole Isacson.